Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid

Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid - Names and Identifiers

Name	Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid
Synonyms	RARECHEM AK PT B040 BOC-D-PHE(3,4-CL 2)-(C*CH2)OH BOC-D-BETA-HOPHE(3,4-DICL)-OH BOC-3,4-DICHLORO-D-BETA-HOMOPHENYLALANINE BOC-(R)-3-AMINO-4-(3,4-DICHLOROPHENYL)BUTANOIC ACID Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid BOC-(R)-3-AMINO-4-(3,4-DICHLORO-PHENYL)-BUTYRIC ACID N-BETA-T-BUTOXYCARBONYL-D-HOMO(3,4-DICHLOROPHENYL)ALANINE N-T-BUTOXYCARBONYL-(R)-3-AMINO-4-(3,4-DICHLOROPHENYL)BUTANOIC ACID
CAS	269396-56-7
EINECS	222-980-0

Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid - Physico-chemical Properties

Molecular Formula	C15H19Cl2NO4
Molar Mass	348.22
Density	1.294
Boling Point	494.8±45.0 °C(Predicted)
pKa	4.36±0.10(Predicted)
Storage Condition	2-8°C

Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid - Risk and Safety

Hazard Class

IRRITANT

Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid - Introduction

Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid is an organic compound with the following properties:

1. Appearance: white crystalline powder.

2. Solubility: Soluble in common organic solvents such as dichloromethane, dimethyl sulfoxide, etc.

The main uses of this compound include the following:

1. organic synthesis: as an intermediate in organic synthesis, it can be used to prepare various drugs, natural products and biologically active compounds.

2. peptide synthesis: can be used as a protective group to protect the amino group on the amino acid side chain.

The preparation of Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid usually includes the following steps:

1. First, (R)-3-hydroxy-4-(3,4-dichlorophenyl) butyric acid was obtained by reacting 1,4-butanediol with 3,4-dichlorobenzoic acid.

2. Next, (R)-3-hydroxy-4-(3,4-dichlorophenyl) butanoic acid was reacted with Boc2O (tert-butoxycarbonyl chloride) in the presence of dihydroxyethyl carbonate to give Boc-(R)-3-Amino-4-(3,4-dichloro-phenyl)-butyric acid.

Regarding the safety information of this compound, the following should be noted:

1. skin and eye irritation: can cause eye and skin irritation. In the operation, should take necessary protective measures, such as wearing protective glasses and gloves.

2. Toxicity: The toxicity of this compound is low, but care should be taken when using and handling. Avoid inhalation and exposure to large amounts of compounds.

3. storage and handling: should be stored in a dry, cool, well-ventilated place, away from fire and oxidant. Avoid mixed storage with acids, alkalis and other chemicals.

Last Update：2024-04-10 22:41:03